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https://hdl.handle.net/1822/42479
Título: | Microfluidic production of hyaluronic acid derivative microfibers to control drug release |
Autor(es): | Agnello, Stefano Gasperini, Luca Reis, R. L. Mano, J. F. Pitarresi, Giovanna Palumbo, Fabio S. Giammona, Gaetano |
Palavras-chave: | Biomaterials Polymers Hyaluronic acid Microfibers Microfluidic technique Polymers Drug delivery |
Data: | 2016 |
Editora: | Elsevier 1 |
Revista: | Materials Letters |
Citação: | Agnello S., Gasperini L., Reis R. L., Mano J. F., Pitarresi G., Palumbo F. S., Giammona G. Microfluidic production of hyaluronic acid derivative microfibers to control drug release, Materials Letters, Vol. 182, pp. 309-313, doi:10.1016/j.matlet.2016.07.014, 2016 |
Resumo(s): | Microfibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability oMicrofibers of a hyaluronic acid amphiphilic derivative (HA-EDA-C18), with incorporated dexamethasone (Dex) as a model bioactive molecule, were obtained by microfluidic technique. Exploiting the ionic strength sensible behavior of HA-EDA-C18, microfibers were formed in baths containing phosphate buffer saline with different salt concentration. The morphology and stability of the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications.f the microfibers were studied. The release profile showed that it was possible to control the release rate of Dex from microfibers changing the salt concentration of the coagulating bath. The results indicated that HA-EDA-C18 microfibers are potentially useful for drug delivery applications. |
Tipo: | Artigo |
Descrição: | "Available online 4 July 2016" |
URI: | https://hdl.handle.net/1822/42479 |
DOI: | 10.1016/j.matlet.2016.07.014 |
ISSN: | 0167-577X |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S0167577X16311089 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
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18794-1-s2.0-S0167577X16311089-main.pdf Acesso restrito! | 535,05 kB | Adobe PDF | Ver/Abrir |