Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/4040
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Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Silva, G. A. | - |
dc.contributor.author | Costa, F. J. | - |
dc.contributor.author | Coutinho, O. P. | - |
dc.contributor.author | Radin, S. | - |
dc.contributor.author | Ducheyne, P. | - |
dc.contributor.author | Reis, R. L. | - |
dc.date.accessioned | 2006-01-19T12:58:04Z | - |
dc.date.available | 2006-01-19T12:58:04Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | "Journal Biomedical Materials Research : Part A". ISSN 1549-3296. 70A:3 (Sept. 2004) 442-449. | eng |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://hdl.handle.net/1822/4040 | - |
dc.description.abstract | The aim of the development of composite materials is to combine the most desired properties of two or more materials. In this work, the biodegradable character, good controlled-release properties, and natural origin of starch-based biomaterials are combined with the bioactive and bone-bonding properties of bioactive glass (BG). Novel, bioactive composite starch-BG microparticles were synthesized starting from a blend of starch and polylactic acid (50%/50% wt) with BG 45S5 powder using a simple emulsion method. Morphological and chemical characterization showed that these particles exhibited a spherical morphology with sizes up to 350 m and that BG 45S5 was incorporated successfully into the composite particles. Upon immersion in a solution simulating body fluids, for periods up to 3 weeks, their bioactive nature was confirmed, as a calcium-phosphate layer resembling biological apatite was formed onto their surface. The short-term cytotoxicity of these materials was also tested by placing 24-h leachables of the materials extracted in culture medium in contact with a fibroblastic cell line (L929) up to 72 h. At this time period, two biochemical tests - MTT and total protein quantification - were performed. The results showed that these materials are not cytotoxic. These results constitute the basis of future encapsulation studies using bone-acting therapeutic agents such as bone morphogenetic proteins or other bone-relevant factors. The particles developed here may be very useful for applications in which controlled release, degradability, and bone-bonding ability are the main requirements. | eng |
dc.description.sponsorship | FCT Foundation for Science and Technology, through funds from the POCTI and/or FEDER programmes. | por |
dc.language.iso | eng | eng |
dc.publisher | Wiley | eng |
dc.rights | openAccess | eng |
dc.subject | Natural origin | eng |
dc.subject | Biodegradable | eng |
dc.subject | Starch | eng |
dc.subject | Bioactive glass | eng |
dc.subject | Bioactive | eng |
dc.subject | Microparticles | eng |
dc.subject | Composites | eng |
dc.subject | Short-term cytotoxicity | eng |
dc.title | Synthesis and evaluation of novel bioactive composite starch/bioactive glass microparticles | eng |
dc.type | article | eng |
dc.peerreviewed | yes | eng |
oaire.citationStartPage | 442 | por |
oaire.citationEndPage | 449 | por |
oaire.citationIssue | 3 | por |
oaire.citationVolume | 70A | por |
dc.identifier.doi | 10.1002/jbm.a.30099 | por |
dc.identifier.pmid | 15293318 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Journal of Biomedical Materials Research: Part A | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |