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https://hdl.handle.net/1822/38525
Título: | Evaluation of antibacterial activity of caffeic acid encapsulated by -cyclodextrins |
Autor(es): | Pinho, Eva Soares, Graça Henriques, Mariana |
Palavras-chave: | Staphylococcus aureus inclusion complex phenolic acid MIC wound infection |
Data: | 2015 |
Editora: | Taylor and Francis |
Revista: | Journal of Microencapsulation: Micro and Nano Carriers |
Citação: | Pinho, Eva; Soares, Graça; Henriques, Mariana, Evaluation of antibacterial activity of caffeic acid encapsulated by -cyclodextrins. Journal of Microencapsulation: Micro and Nano Carriers, 32(8), 804-810, 2015 |
Resumo(s): | Context: Caffeic acid is described as antibacterial, but this bioactive molecule has some issues regarding solubility and stability to environmental stress. Thus, encapsulation devices are required. Objective: The aim of this work was to study the effect of the caffeic acid encapsulation by cyclodextrins on its antibacterial activity. Materials and methods: The interactions between the caffeic acid and three cyclodextrins (-cyclodextrin (CD), 2-hydroxypropyl--cyclodextrin (HPCD) and methyl--cyclodextrin were study. Results and discussion: The formation of an aqueous soluble inclusion complex was confirmed for CD and HPCD with a 1:1 stoichiometry. The CD/caffeic acid complex showed higher stability than HPCD/caffeic acid. Caffeic acid antibacterial activity was similar at pH 3 and pH 5 against the three bacteria (K. pneumoniae, S. epidermidis and S. aureus). Conclusions: The antibacterial activity of the inclusion complexes was described here for the first time and it was shown that the caffeic acid activity was remarkably enhanced by the cyclodextrins encapsulation. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/38525 |
DOI: | 10.3109/02652048.2015.1094531 |
ISSN: | 0265-2048 |
e-ISSN: | 1464-5246 |
Versão da editora: | http://www.tandfonline.com/action/journalInformation?journalCode=imnc20 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_23436_1.pdf | 1,16 MB | Adobe PDF | Ver/Abrir |