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https://hdl.handle.net/1822/38383
Título: | Serum total and bone alkaline phosphatase levels and their correlation with serum minerals over the lifespan of sheep |
Autor(es): | Sousa, Cristina P. Azevedo, Jorge T. Silva, Amélia M. Viegas, Carlos A. Reis, R. L. Gomes, Manuela E. Dias, Isabel R. |
Palavras-chave: | Ageing Bone alkaline phosphatase Minerals Physiologic state Sheep Total alkaline phosphatase |
Data: | 2014 |
Editora: | Akadémiai Kiadó |
Revista: | Acta Veterinaria Hungarica |
Citação: | Sousa C. P., Azevedo J. T., Silva A. M., Viegas C. A., Reis R. L., Gomes M. E., Dias I. R. Serum total and bone alkaline phosphatase levels and their correlation with serum minerals over the lifespan of sheep. Acta Veterinaria Hungarica, Acta Veterinaria Hungarica, Vol. 62, Issue 2, pp. 205-214, doi:10.1556/AVet.2013.049, 2013 |
Resumo(s): | This study aimed to assess serum total alkaline phosphatase (ALP) and its bone isoform (BALP) levels during the ageing and in different physiologic states of sheep, in order to expand the knowledge about the variation of these biomarkers over the sheep lifespan. Ninety female sheep were divided into nine groups of various ages and physiological states (dry, lactation and pregnancy). Serum ALP, BALP and mineral levels were determined by commercial immunoassay, molecular absorbance spectrophotometry and chemical luminescence for BALP determination. Serum ALP and BALP decreased as sheep aged, and no statistically significant differences were obtained between ewes in different physiologic states. The continuous decline of serum BALP concentration along the sheep lifespan, namely in mature and old sheep, is a sign of decreasing bone turnover associated with ageing. Serum calcium concentrations increased slightly until 2 years of age and then showed a tenuous but statistically significant decrease in mature sheep, while serum phosphorus maintained an uninterrupted decrease as sheep matured. The knowledge of serum values of bone biomarkers throughout the sheep lifespan may be useful in preclinical orthopaedic research studies and for animal science studies using sheep. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/38383 |
DOI: | 10.1556/AVet.2013.049 |
ISSN: | 1588-2705 0236-6290 |
Versão da editora: | http://www.akademiai.com/doi/abs/10.1556/AVet.2013.049?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed& |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18303-CristinaSousa_ActaVetHung_2014.pdf | 207,32 kB | Adobe PDF | Ver/Abrir |