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https://hdl.handle.net/1822/35093
Título: | Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase |
Autor(es): | Gonçalves, Idalina Botelho, C. M. Teixeira, Ana Abreu, Ana S. Hilliou, L. Carla Manuela Pereira Marinho da Paulo, Artur Cavaco |
Palavras-chave: | Methylparaben Trimethoprim Tyrosinase Poly(hydroxybenzene) Conjugates Antimicrobial |
Data: | Mai-2015 |
Editora: | Springer |
Revista: | Applied Microbiology and Biotechnology |
Citação: | Gonçalves, Idalina; Botelho, C. M.; Teixeira, Ana; Abreu, A. S.; Hilliou, L.; Silva, Carla; Paulo, Artur Cavaco, Antimicrobial lubricant formulations containing poly(hydroxybenzene)-trimethoprim conjugates synthesized by tyrosinase. Applied Microbiology and Biotechnology, 99(10), 4225-4235, 2015 |
Resumo(s): | Poly(hydroxybenzene)-trimethoprim conjugates were prepared using methylparaben as substrate of the oxida- tive enzyme tyrosinase. MALDI-TOF MS analysis showed that the enzymatic oxidation of methylparaben alone leads to the poly(hydroxybenzene) formation. In the presence of tri- methoprim, the methylparaben tyrosinase oxidation leads poly(hydroxybenzene)-trimethoprim conjugates. All of these compounds were incorporated into lubricant hydroxyethyl cellulose/glycerol mixtures. Poly(hydroxybenzene)-trimetho- prim conjugates were the most effective phenolic structures against the bacterial growth reducing by 96 and 97 % of Escherichia coli and Staphylococcus epidermidis suspen- sions, respectively (after 24 h). A novel enzymatic strategy to produce antimicrobial poly(hydroxybenzene)-antibiotic conjugates is proposed here for a wide range of applications on the biomedical field. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/35093 |
DOI: | 10.1007/s00253-015-6509-1 |
ISSN: | 0175-7598 |
e-ISSN: | 1432-0614 |
Versão da editora: | http://www.springer.com/chemistry/biotechnology/journal/253 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series IPC - Artigos em revistas científicas internacionais com arbitragem |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_19859_1.pdf | 702,83 kB | Adobe PDF | Ver/Abrir |