Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/32863Registo completo
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Pinho, Eva | por |
| dc.contributor.author | Henriques, Mariana | por |
| dc.contributor.author | Soares, Graça M. B. | por |
| dc.date.accessioned | 2015-01-15T10:49:25Z | - |
| dc.date.available | 2015-01-15T10:49:25Z | - |
| dc.date.issued | 2014 | - |
| dc.identifier.citation | Pinho, Eva; Henriques, Mariana; Soares, Graça M. B., Caffeic acid loading wound dressing: physicochemical and biological characterization. Therapeutic Delivery, 5(10), 1063-1075, 2014 | por |
| dc.identifier.issn | 2041-5990 | por |
| dc.identifier.uri | https://hdl.handle.net/1822/32863 | - |
| dc.description.abstract | AIM: Caffeic acid has been described as active against bacteria commonly isolated from wound infections. However, its low stability and poor solubility reduce caffeic acid applicability as a pharmaceutical product. These parameters can be enhanced by complexation with cyclodextrin. The main goal of the present work was to incorporate caffeic acid on cyclodextrin-based hydrogels capable of controlled delivery, in order to be used as antibacterial wound dressing. MATERIALS & METHODS: Cyclodextrin-based hydrogels were prepared by direct crosslinking of -cyclodextrin or hydroxypropyl--cyclodextrin with 1,4-butanediol diglycidyl ether in the presence of hydroxypropyl methylcellulose. RESULTS: The hydrogels obtained combine good physicochemical properties (viscoelasticity, superabsorbency and high ability to retain and deliver caffeic acid) with the preservation of caffeic acid' antibacterial activity and effect on fibroblasts, with gel--cyclodextrin the most suited. CONCLUSION: The hydrogels obtained could be useful as caffeic acid delivery-system devices for the treatment of wound infections. | por |
| dc.description.sponsorship | The authors are grateful for the FCT StrategicProject PEst-OE/EQB/LA0023/2013 and the Project 'BioHealth- Biotechnology and Bioengineering approaches to improve healthquality', ref. NORTE-07-0124-FEDER-000027, co-funded by the 'Programa Operacional Regional do Norte' (ON. 2-O Novo Norte), QREN, FEDER. The authors also acknowledge the project 'Consolidating Research Expertise and Resources on Cellular and Molecular Biotechnology at CEB/IBB', ref. FCOMP-01-0124-FEDER-027462. This work is also funded by FEDER funds through the Operational Programme for Competitiveness Factors-COMPETE and National Funds through FCT- Foundation for Science and Technology under the project PEst-C/CTM/UI0264/2011. Additionally, the authors would like to thank the FCT for the grant for E Pinho (SFRH/BD/62665/2009).The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | por |
| dc.language.iso | eng | por |
| dc.publisher | Future Science Ltd. | por |
| dc.rights | openAccess | por |
| dc.title | Caffeic acid loading wound dressing : physicochemical and biological characterization | por |
| dc.type | article | - |
| dc.peerreviewed | yes | por |
| dc.relation.publisherversion | http://www.future-science.com/loi/tde | por |
| dc.comments | CEB18089 | por |
| sdum.publicationstatus | published | por |
| oaire.citationStartPage | 1063 | por |
| oaire.citationEndPage | 1075 | por |
| oaire.citationIssue | 10 | por |
| oaire.citationTitle | Therapeutic Delivery | por |
| oaire.citationVolume | 5 | por |
| dc.date.updated | 2015-01-15T10:09:42Z | - |
| dc.identifier.eissn | 2041-5990 | - |
| dc.identifier.doi | 10.4155/TDE.14.77 | por |
| dc.identifier.pmid | 25418266 | por |
| dc.subject.wos | Science & Technology | por |
| sdum.journal | Therapeutic Delivery | por |
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Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| document_18089_1.pdf | 1,6 MB | Adobe PDF | Ver/Abrir |
