Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/32062
Título: | Alterations in the Staphylococcus epidermidis biofilm transcriptome following interaction with whole human blood |
Autor(es): | França, Ângela Carvalhais, Virgínia Maria Dinis Maira-Litrán, Tomas Vilanova, Manuel Cerca, Nuno Pier, Gerald B. |
Palavras-chave: | RNA sequencing Pathogenesis Iron metabolism |
Data: | 2014 |
Editora: | Wiley |
Revista: | Pathogens and Disease |
Citação: | França, Ângela; Carvalhais, V.; Maira-Litran, T.; Vilanova, M.; Cerca, Nuno; Pier, G. B., Alterations in the Staphylococcus epidermidis biofilm transcriptome following interaction with whole human blood. Pathogens and Disease, 70(3), 444-448, 2014 |
Resumo(s): | Staphylococcus epidermidis biofilm formation on the surface of intravenous catheters is responsible for 22% of the cases of bloodstream infections, in patients in intensive care units in the USA. The ability of S. epidermidis to withstand the high bactericidal activity of human blood is therefore crucial for systemic dissemination. To identify the genes involved in the bacterium's survival, the transcriptome of S. epidermidis biofilms, upon contact with human blood, was assessed using an ex vivo model. Our results showed an increased transcription of genes involved in biosynthesis and metabolism of amino acids, small molecules, carboxylic and organic acids, and cellular ketones. One of the striking changes observed 4 h of S. epidermidis exposure to human blood was an increased expression of genes involved in iron utilization. This finding suggests that iron acquisition is an important event for S. epidermidis survival in human blood. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/32062 |
DOI: | 10.1111/2049-632X.12130 |
ISSN: | 2049-632X |
e-ISSN: | 2049-632X |
Versão da editora: | http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)2049-632X |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_17432_1.pdf | 191,32 kB | Adobe PDF | Ver/Abrir |