Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/31686
Título: | A novel crosslinked hyaluronic Acid nanogel for drug delivery |
Autor(es): | Pedrosa, Sílvia Santos Gonçalves, Catarina David, Laurent Gama, F. M. |
Data: | 2014 |
Editora: | John Wiley and Sons |
Revista: | Macromolecular bioscience |
Citação: | Pedrosa, S.S.; Gonçalves, Catarina; David, Laurent; Gama, F.M. A novel crosslinked hyaluronic acid nanogel for drug delivery Macromolecular Bioscience 14(11) 1556-1568, 2014. |
Resumo(s): | An amphiphilic hyaluronic acid conjugate is successfully developed based on grafting a thiolated hydrophobic molecule to the polysaccharide backbone. The engineered conjugate is capable of assembling into nanostructures once dispersed in water, with average diameter of 80.2 ± 0.4 nm (n = 5), stable up to 6 months. The thiolated HyA conjugate is reticulated by dissulfide bond with a homofunctional crosslinker—1,4-Bis(3-[2-pyridyldithio]propionamido)butane (DPDPB). The drug loading efficiency of the reticulated and non-reticulated nanogel is accessed with two hydrophobic drugs, curcumin and simvastatin. Results suggest that crosslinked nanogel exhibit higher stability upon dilution and drug loading efficiency and proves to be a redox sensitive material. The nanogels hold great potential as stealth carriers of lipophilic drugs. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/31686 |
DOI: | 10.1002/mabi.201400135 |
ISSN: | 1616-5187 |
e-ISSN: | 1616-5195 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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document_18037_1.pdf | 1,39 MB | Adobe PDF | Ver/Abrir |