Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/31545
Título: | Assembling human Platelet Lysate into multiscale 3D scaffolds for bone tissue engineering |
Autor(es): | Oliveira, Sara M. Reis, R. L. Mano, J. F. |
Palavras-chave: | Bone Carrageenan Layer-by-layer Multiscale Platelet Lysate Sulfated polysaccharides layer-by-layer assembling osteogenesis multiscale scaffold instructive |
Data: | 2015 |
Editora: | ACS |
Revista: | ACS Biomaterials Science and Engineering |
Citação: | Oliveira S. M., Reis R. L., Mano J. F. Assembling human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering, ACS Biomaterials Science & Engineering, Vol. 1, Issue 1, DOI: 10.1021/ab500006x, 2015. |
Resumo(s): | Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/meso-scale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-by-layer and shaped into fibrils by freeze-drying. We show that osteogenic induction of stem cells is tunable within a low range of layers. This approach has the potential to develop new scaffolds with enhanced cell-instructive capabilities using affordable autologous sources of bioactive molecules. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/31545 |
DOI: | 10.1021/ab500006x |
ISSN: | 2373-9878 |
Versão da editora: | http://pubs.acs.org/doi/abs/10.1021/ab500006x |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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18231-Assembling human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering.pdf Acesso restrito! | 3,05 MB | Adobe PDF | Ver/Abrir |