Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/29372
Título: | The selective COX-2 inhibitor etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment |
Autor(es): | Rodrigues, Manuel Lima Lamas, Nuno Jorge Fernandes, Ana Valle Cruz, Andrea Vieira, Artur Jorge Gomes Oliveira, Pedro Pedrosa, Jorge Castro, António G. Reis, R. M. Baltazar, Fátima Almeida, Armando |
Palavras-chave: | Neurogenic laryngitis Nasogastric intubation (NGI) model Quantitative real-time QRT-PCR Selective COX-2 inhibitor Tumor necrosis factor-a (TNF-a) |
Data: | 2010 |
Editora: | Springer |
Revista: | Inflammation Research |
Resumo(s): | OBJECTIVE: A randomised experimental study was used to evaluate the therapeutic effect of a selective cyclooxygenase-2 (COX-2) inhibitor in neurogenic laryngitis. MATERIALS AND METHODS: Male Wistar Han rats were subjected to the nasogastric intubation model (NGI) of laryngitis for 1 and 2 weeks. The NGI animals were divided into three groups: (1) treated with COX-2 inhibitor Etoricoxib, (2) vehicle and (3) non-intubated animals. A fourth group of animals was submitted to NGI only. Laryngeal sections were immunostained for substance P (SP) and calcitonin gene-related peptide (CGRP) fibre-immunoreactivity (IR) and quantification of COX-2 positive cells through stereological analysis. The expression of COX-2, interleukins IL-1beta, IL-6, IL-10 and tumour necrosis factor-alpha (TNF-alpha) was determined by quantitative real time QRT-PCR. TREATMENT: Etoricoxib (6 mg/kg/day) was prepared in 0.9% sterile saline with 5% glucose (vehicle) and administered daily during 1 or 2 weeks. RESULTS: Treatment for 1 week with Etoricoxib attenuated the CGRP-IR fibre depletion, the COX-2-IR increased cell number and the TNF-alpha and COX-2 mRNA increased levels induced by NGI. Two weeks of treatment had no beneficial effect. CONCLUSIONS: Etoricoxib is effective in neurogenic laryngitis for limited periods of administration, indicating that selective COX-2 inhibitors should be evaluated in the future. |
Tipo: | Artigo |
Descrição: | The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment. |
URI: | https://hdl.handle.net/1822/29372 |
DOI: | 10.1007/s00011-010-0185-5 |
ISSN: | 1023-3830 |
Versão da editora: | http://link.springer.com/article/10.1007%2Fs00011-010-0185-5 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
lima-rodrigues m_ inflamm res 2010 posp.pdf | 1,81 MB | Adobe PDF | Ver/Abrir |