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https://hdl.handle.net/1822/28252
Título: | The impact of GGH -401C>T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer |
Autor(es): | Silva, Inês Hilário Silva, Cristina Nogueira Figueiredo, Tiago Lombo, Liliana Faustino, Ilda Catarino, Raquel Nogueira, Augusto Pereira, Deolinda Medeiros, Rui |
Palavras-chave: | cervical cancer GGH Polymorphism Cisplatin response olymorphism |
Data: | 2013 |
Editora: | Elsevier 1 |
Revista: | Gene |
Resumo(s): | Aims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C > T polymorphism in treatment response in cervical cancer. Methods: We retrospectively reviewed the clinical data of 167 patients with bulky cervical cancer submitted to cisplatin-based chemoradiotherapy. The genotypes of GGH -401C > T SNP were determined by real-time PCR and statistical analysis was performed by chi(2) test and survival analysis. Results: The genotypes of GGH-401C > T were significantly associated with the response to platinum-based chemoradiotherapy. Treatment response was higher in patients carrying the CC genotype, who presented a significant increased chance of treatment response (survival time in months/genotype: 91 for CC Vs 72 for CT/TT; p = 0.035, log rank test). A Cox regression analysis accordingly showed that the presence of the T allele was significantly linked to a worse treatment response (HR = 3.036; CI 95% 1.032-8.934, p = 0.044). Conclusions: The results of our study suggested the potential interest of GGH -401C > T as a predictive factor of the outcome of cervical carcinoma treated with cisplatin-based chemoradiotherapy. (c) 2012 Elsevier B.V. All rights reserved. |
Tipo: | Artigo |
Descrição: | Uncorrected proof |
URI: | https://hdl.handle.net/1822/28252 |
DOI: | 10.1016/j.gene.2012.10.038 |
ISSN: | 0378-1119 |
Versão da editora: | http://www.journals.elsevier.com/gene/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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silva ines h_gene 2013 posp.pdf | 227,86 kB | Adobe PDF | Ver/Abrir |