Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/28177
Título: | Interleukin-6 gene -174G>C and -636G>C promoter polymorphisms and prostate cancer risk |
Autor(es): | Magalhães, J. F. Cortinhas, A. J. Albuquerque, C. M. Baptista, C. S. Ribeiro, R. Viegas, Carlos A. Matos, Augusto Machado, João Pires, Maria A. Pinto, Henrique Guedes Bessa, A. Martins Leitão, J. C. Bastos, E. |
Palavras-chave: | Interleukin-6 Polymorphism Prostate cancer Risk |
Data: | 2013 |
Editora: | Springer |
Revista: | Molecular biology reports |
Resumo(s): | Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes,IL-6polymorphisms may modulate PCa risk.IL-6−174 G>C (rs 1800795, also designated −236 G>C) and −636 G>C (rs 1800796, also designated −572 G>C) promoter polymorphisms have been implicated in PCa susceptibility, albeit still controversial. A literature search using PubMed and Highwire databases was conducted, resulting in eight case–control studies concerning theIL-6−174 G>C polymorphism (11,613 PCa cases and 13,992 controls) and four case–control publications regarding theIL-6−636 G>C polymorphism (1,941 PCa cases and 3,357 controls). In order to derive a more precise estimation, a meta-analysis based upon these selected case–control studies was performed. There was no significant association betweenIL-6−174 G>C polymorphism and PCa increased risk. Nevertheless, the presence of allele C and the CC genotype were statistically significantly associated with decreased PCa risk in the overall analysis forIL-6−636 G>C polymorphism. Additional studies in larger samples and analyses of functional repercussions of these SNPs in prostate tumor cells are necessary to validate these findings. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/28177 |
DOI: | 10.1007/s11033-012-2079-9 |
ISSN: | 0301-4851 1573-4978 |
Versão da editora: | http://dx.doi.org/10.1007/s11033-012-2079-9 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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17901-10.1007-11033-012-2079-9.pdf Acesso restrito! | 206,32 kB | Adobe PDF | Ver/Abrir |