Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/27954
Título: | Lipocalin-2 is involved in emotional behaviors and cognitive function |
Autor(es): | Ferreira, Ana Catarina Pinto, Vítor Mesquita, Sandro Novais, Ashley Cruz Sousa, João Carlos Neves, Margarida Correia Sousa, Nuno Palha, Joana Almeida Marques, Fernanda |
Palavras-chave: | Lipocalin-2 Behavior Anxiety Depression Hippocampus |
Data: | 2013 |
Editora: | Frontiers Media |
Revista: | Frontiers in Cellular Neuroscience |
Resumo(s): | Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cognitive impairment in spatial learning tasks. These behavioral alterations were associated with a hyperactivation of the hypothalamic-pituitary-adrenal axis and with an altered brain cytoarchitecture in the hippocampus. More specifically, we found that the granular and pyramidal neurons of the ventral hippocampus, a region described to be associated with emotion, were hypertrophic, while neurons from the dorsal hippocampus, a region implicated in memory and cognition, were atrophic. In addition, LCN2-null mice presented synaptic impairment in hippocampal long-term potentiation. Whether the LCN2 effects are mediated through modulation of the level of corticosteroids or through a novel mechanism, the present observations bring further into light this immune-related protein as a player in the fine-tuning of behavior and of synaptic activity. |
Tipo: | Artigo |
Descrição: | Lipocalin-2 is involved in emotional behaviors and cognitive function |
URI: | https://hdl.handle.net/1822/27954 |
DOI: | 10.3389/fncel.2013.00122 |
ISSN: | 1662-5102 |
Versão da editora: | http://www.frontiersin.org/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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ferreira ac_front cells neurosc 2013.pdf | 977,92 kB | Adobe PDF | Ver/Abrir |