Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/27519
Título: | Cyclodextrin-based hydrogels toward improved wound dressings |
Autor(es): | Pinho, Eva Patrícia Paiva Santos Grootveld, Martin Soares, Graça M. B. Henriques, Mariana |
Palavras-chave: | Bioactive molecules Carriers Cross-link agent Drug delivery Supramolecular structures |
Data: | Dez-2014 |
Editora: | Taylor and Francis |
Revista: | Critical Reviews in Biotechnology |
Citação: | Critical Reviews in Biotechnology, Vol. 34, No. 4 , Pages 328-337, December 2014. |
Resumo(s): | Optimal wound dressings should be capable of mechanical wound protection and also facilitate the healing process via maintenance of suitable environmental conditions and the controlled delivery of bioactive molecules. Hydrogels present suitable properties for wounddressing applications such as good biocompatibility, together with a high water content, the latter of which is important for the maintenance of a moist environment and ready removal from the wound with a minimal level of associated pain. However, their properties as drug delivery systems can be improved by the use of cyclodextrins as cross-linking agents. Cyclodextrins have been extensively used as ‘‘carriers’’ on food, textile, cosmetic and, most especially, in the pharmaceutical industry in view of their powerful complexation abilities and biocompatibilities, together with further desirable characteristics. The conjugation of cyclodextrins with hydrogels may allow the achievement of an optimal wound-dressing material, because the hydrogel component will maintain the moist environment required for the healing process, and the cyclodextrin moiety has the ability to protect and modulate the release of bioactive molecules. Therefore, this review aims to gather information regarding cyclodextrin-based hydrogels for possible wound-dressing applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/27519 |
DOI: | 10.3109/07388551.2013.794413 |
ISSN: | 0738-8551 |
e-ISSN: | 1549-7801 |
Versão da editora: | http://informahealthcare.com/doi/abs/10.3109/07388551.2013.794413 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Crit Rev Biotech EP 2013.pdf Acesso restrito! | 400,4 kB | Adobe PDF | Ver/Abrir |