Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/26035
Título: | Signaling pathways influencing tumor microenvironment and their exploitation for targeted drug delivery |
Autor(es): | Singh, Caroline Jeya Sheeba Daniel Sunder Marslin, Gregory Mary, Revina Ann Gregory, Franklin |
Palavras-chave: | Tumor microenvironment Functionalization Signalling pathways Nanoparticle-mediated drug delivery Active targeting signaling pathways |
Data: | 2014 |
Editora: | Walter de Gruyter GmbH |
Revista: | Nanotechnol Reviews |
Resumo(s): | In the recent years, the “tumor microenvironment” has been receiving growing attention due to its involvement in neoplastic transformation, tumor growth, invasion and protection of tumor cells from host immune response. All these events are facilitated by chemical signals produced by the tumor as well as the surrounding stromal cells. This review is divided into two main parts in which the first part discusses the receptor tyrosine kinase (RTK)-mediated growth factor signaling, steroid hormone signaling, ancient signaling pathways and other molecules that are involved in tumorigenesis and how they interact with each other to create a complex tumor microenvironment. In the second part, we bring together the recent nanocarriers-mediated drug delivery approaches to target the signaling pathways/molecules present in the tumor microenvironment. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/26035 |
DOI: | 10.1515/ntrev-2013-0032 |
ISSN: | 2191-9097 2191-9089 |
Versão da editora: | http://www.degruyter.com/view/j/ntrev.just-accepted/ntrev-2013-0032/ntrev-2013-0032.xml |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Signaling pathways, tumor microenvironment, and targeted drug delivery.pdf | Free access to full text | 1,65 MB | Adobe PDF | Ver/Abrir |