Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/25524
Título: | Proteomic approach to Pseudomonas aeruginosa adaptive resistance to benzalkonium chloride |
Autor(es): | Machado, Idalina Coquet, Laurent Jouenne, Thierry Pereira, Maria Olívia |
Palavras-chave: | P. aeruginosa Proteome Chemical adaptation |
Data: | 2013 |
Editora: | Elsevier 1 |
Revista: | Journal of proteomics |
Resumo(s): | This study aimed to assess the membrane modifications in Pseudomonas aeruginosa after continuous exposure to increasing doses of benzalkonium chloride (BC). Two different concentrations were used, 0.9 and 12.0 mM. Proteomic investigations revealed that the range of the outermembrane proteome alterations following continuous exposure is very low, i.e. about 10% and BC concentration dependent. Adapted cells revealed different expressions of key proteins frequently reported as involved in acquired resistance mechanisms. Porins (OprF and OprG) and lipoproteins (OprL and OprI) were underexpressed when the higher adaptation concentration (12 mM) was used. Some of thesemembrane alterations have been described as involved in the acquired resistance to antibiotics, suggesting possible commonmechanisms between these two types of resistance. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/25524 |
DOI: | 10.1016/j.jprot.2013.04.030 |
ISSN: | 1874-3919 |
e-ISSN: | 1874-3919 |
Versão da editora: | www.elsevier.com/locate/jprot |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series |