Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/25221
Título: | Self-collection for high-risk HPV detection in Brazilian women using the care HPV™ test |
Autor(es): | Lorenzi, Adriana Tarlá Fregnani, José Humberto Possati-Resende, Júlio César Neto, Cristovam Scapulatempo Villa, Luisa Lina Longatto Filho, Adhemar |
Palavras-chave: | Human papillomavirus Cervical cancer Self-sampling Molecular test Screening |
Data: | 2013 |
Editora: | Elsevier 1 |
Revista: | Gynecologic Oncology |
Resumo(s): | Cervical cancer is the second most common cancer among Brazilian women. High-risk human papillomavirus (hr-HPV) persistence is the primary cause of cervical neoplasia. Early detection of hr-HPV is important for identifying women at risk for developing cervical lesions. Approximately 85% of new cases of cervical cancer worldwide and 50% of the total cervical cancer deaths occurred in developing countries. Here, a new methodology to support a cervical cancer screening program was evaluated in women from various Brazilian regions. METHODS: Two thousand women aged 18-77years were enrolled in an opportunistic cervical cancer screening program and were randomized into self-vaginal or health professional-guided cervical sampling groups. The Qiagen careHPV™ test was performed on all samples. Pap tests were performed on all women using liquid-based cytology. RESULTS: Positive hr-HPV results were obtained in 12.3% (245/2000) of women; similar rates were observed in self- or health professional-collected samples. Eighty-nine percent (1719/2000) of cervical cytologies classified as normal were negative to hr-HPV. Among the cytological samples, 36.6% classified as ASC-US+ were positive to hr-HPV, 78.8% were LSIL and 75.0% were HSIL. CONCLUSIONS: Self-sampled and health professional-sampled vaginal/cervical specimens did not differ in their rates of detection of hr-HPV. Therefore, HPV DNA testing in self-sampled vaginal cells is an alternative to primary screening in low-resource settings. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/25221 |
DOI: | 10.1016/j.ygyno.2013.07.092 |
ISSN: | 0090-8258 |
Versão da editora: | www.journals.elsevier.com/gynecologic-oncology/? |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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lorenzi a_gynec onc 2013 ip.pdf | 200,55 kB | Adobe PDF | Ver/Abrir |