Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/24437Registo completo
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Gaharwar, Akhilesh K. | - |
| dc.contributor.author | Mihaila, Silvia M. | - |
| dc.contributor.author | Swami, A. | - |
| dc.contributor.author | Patel, A. | - |
| dc.contributor.author | Sant, A. | - |
| dc.contributor.author | Reis, R. L. | - |
| dc.contributor.author | Marques, A. P. | - |
| dc.contributor.author | Gomes, Manuela E. | - |
| dc.contributor.author | Khademhosseini, Ali | - |
| dc.date.accessioned | 2013-06-17T15:58:45Z | - |
| dc.date.available | 2013-06-17T15:58:45Z | - |
| dc.date.issued | 2013-05 | - |
| dc.date.submitted | 2013-05 | - |
| dc.identifier.issn | 1521-4095 (on-line) | por |
| dc.identifier.uri | https://hdl.handle.net/1822/24437 | - |
| dc.description.abstract | Novel silicate nanoplatelets that induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in the absence of any osteoinductive factor are reported. The presence of the silicate triggers a set of events that follows the temporal pattern of osteogenic differentiation. These findings underscore the potential applications of these silicate nanoplatelets in designing bioactive scaffolds for musculoskeletal tissue engineering. | por |
| dc.description.sponsorship | A. K. G. and A. K. designed the study. A. K. G., S. M. M., A. S., A. P., and S. S. performed the experiments. A. K. G. and S. M. M. analyzed the results. A. K. G. and A. S. investigated cell-nanoparticles interactions. R. L. R., A. P. M., and M. G. provided technical support. A. K. G. and A. K. wrote the paper. The manuscript was revised by all the authors and was approved to the final version of the manuscript. A. K. G. would like to thank Prof. Robert S. Langer for his technical insight and feedback throughout the project and acknowledges financial support from MIT-Portugal Program (MPP-09Call-Langer-47). S. M. M. thanks the Portuguese Foundation for Science and Technology (FCT) for the personal grant SFRH/BD/42968/2008 (MIT-Portugal Program) and the financial support of MIT/ECE/0047/2009 project. A. S. would like to acknowledge the National Institutes of Health (NIH) (CA151884) and the David Koch-Prostate Cancer Foundation Award in Nanotherapeutics. A. P. is supported by postdoctoral fellowship by Natural Science and Engineering Research Council (NSERC), Canada. S. S. acknowledges the postdoctoral fellowship awarded by Le Fonds Quebecois de la Recherche sur la Nature et les Technologies (FQRNT), Quebec, Canada and interdisciplinary training fellowship awarded by System-based Consortium for Organ Design and Engineering (SysCODE). This research was funded by the US Army Engineer Research and Development Center, the Institute for Soldier Nanotechnology, the NIH (EB009196; DE019024; EB007249; HL099073; AR057837), and the National Science Foundation CAREER award (A.K.). | por |
| dc.language.iso | eng | por |
| dc.publisher | Wiley-VCH Verlag | por |
| dc.rights | restrictedAccess | por |
| dc.subject | Osteogenic differentiation | por |
| dc.subject | Osteoinductive | por |
| dc.subject | Silicate nanoplatelets | por |
| dc.subject | Stem cells | por |
| dc.subject | synthetic clay | por |
| dc.subject | laponite nanoparticles | por |
| dc.subject | human mesenchymal stem cells | por |
| dc.subject | tissue engineering | por |
| dc.title | Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells | por |
| dc.type | article | - |
| dc.peerreviewed | yes | por |
| dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/adma.201300584/abstract | por |
| dc.comments | http://www.3bs.uminho.pt/node/17542 | por |
| sdum.publicationstatus | published | por |
| oaire.citationStartPage | 3329 | por |
| oaire.citationEndPage | 3336 | por |
| oaire.citationIssue | 24 | por |
| oaire.citationTitle | Advanced Materials | por |
| oaire.citationVolume | 25 | por |
| dc.date.updated | 2013-06-14T15:21:22Z | - |
| dc.identifier.doi | 10.1002/adma.201300584 | por |
| dc.identifier.pmid | 23670944 | por |
| dc.subject.wos | Science & Technology | por |
| sdum.journal | Advanced Materials | por |
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Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| 17542-Silvia Mihaila_AdvMat_Bioactive Silicate Nanoplatelets for Osteogenic Differentiation of Human Mesenchymal Stem Cells.pdf Acesso restrito! | 1,62 MB | Adobe PDF | Ver/Abrir |
