Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22754
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Campo DC | Valor | Idioma |
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dc.contributor.author | Duarte, Ana Rita C. | - |
dc.contributor.author | Mano, J. F. | - |
dc.contributor.author | Reis, R. L. | - |
dc.date.accessioned | 2013-01-21T16:19:02Z | - |
dc.date.available | 2013-01-21T16:19:02Z | - |
dc.date.issued | 2012 | - |
dc.date.submitted | 2012-12 | - |
dc.identifier.issn | 0896-8446 | por |
dc.identifier.uri | https://hdl.handle.net/1822/22754 | - |
dc.description.abstract | The aim of this study was to evaluate the possibility of preparing chitosan porous matrixes using supercritical fluid technology. Supercritical immersion precipitation technique was used to prepare scaffolds of a natural biocompatible polymer, chitosan for tissue engineering purposes. The physicochemical and biological properties of chitosan make it an excellent material for the preparation of drug delivery systems and for the development of new biomedical applications in many fields from skin to bone or cartilage. Supercritical assisted phase inversion experiments were carried out and the effect of different organic solvents on the morphology of the scaffolds was assessed. Chitosan scaffold morphology, porosity and pore size were evaluated by SEM and micro-CT. A thermodynamic analysis of the process was carried out and insights on the solubility parameter and Flory–Huggins interaction parameters are given. The preparation of a highly porous and interconnected structure of a natural material, chitosan, using a clean and environmentally friendly technology constitutes a new processing technology for the preparation of scaffolds for tissue engineering using these materials. | por |
dc.description.sponsorship | Ana Rita C. Duarte is grateful for financial support from Fundacao para a Ciencia e Tecnologia (FCT) through the grant SFRH/BPD/34994/2007. The support through the FCT project PTDC/QUI/68804/2006 is also acknowledged. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/68804/PT | - |
dc.rights | openAccess | por |
dc.subject | Chitosan | por |
dc.subject | Supercritical fluids | por |
dc.subject | Solubility parameter | por |
dc.subject | Flory-Huggins interaction parameter | por |
dc.subject | Scaffolds | por |
dc.subject | Tissue engineering | por |
dc.title | The role of organic solvent on the preparation of chitosan scaffolds by supercritical assisted phase inversion | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.supflu.2010.12.004 | - |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 323 | por |
oaire.citationEndPage | 326 | por |
oaire.citationTitle | Journal of Supercritical Fluids | por |
oaire.citationVolume | 72 | por |
dc.identifier.doi | 10.1016/j.supflu.2010.12.004 | - |
dc.subject.wos | Science & Technology | por |
sdum.journal | The Journal of Supercritical Fluids | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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JSupFlu_11_Role organic solvent phase inversion.pdf | 786,29 kB | Adobe PDF | Ver/Abrir |