Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22089
Título: | Cannabinoid modulation of noradrenergic circuits: Implications for psychiatric disorders |
Autor(es): | Carvalho, Ana Raquel Franky Gomes Bockstaele, Elisabeth J. Van |
Palavras-chave: | Adrenergic receptor Cannabinoid receptor type 1 Nucleus accumbens Nucleus of the solitary tract Sprague–Dawley |
Data: | 1-Jul-2012 |
Editora: | Elsevier 1 |
Revista: | Progress in Neuro-Psychopharmacology & Biological Psychiatry |
Resumo(s): | The interaction between the endocannabinoid system and catecholaminergic circuits has gained increasing attention as it is recognized that the development of synthetic cannabinoid receptor agonists/antagonists or compounds targeting endocannabinoid synthesis/metabolism may hold some therapeutic potential for the treatment of psychiatric disorders. The noradrenergic system plays a critical role in the modulation of emotional state, primarily related to anxiety, arousal, and stress. Recent evidence suggests that the endocannabinoid system mediates stress responses and emotional homeostasis, in part, by targeting noradrenergic circuits. This review summarizes our current knowledge regarding the anatomical substrates underlying regulation of noradrenergic circuitry by the endocannabinoid system. It then presents biochemical evidence showing an important effect of cannabinoid modulation on adrenergic receptor signaling. Finally, new evidence from behavioral pharmacology studies is provided demonstrating that norepinephrine is a critical determinant of cannabinoid-induced aversion, adding another dimension to how central noradrenergic circuitry is regulated by the cannabinoid system |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/22089 |
DOI: | 10.1016/j.pnpbp.2012.01.008 |
ISSN: | 0278-5846 |
Versão da editora: | http://www.sciencedirect.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Carvalho AF_Prog Neuropsychopharmacol Biol Psychiatry 2012 prep.pdf Acesso restrito! | Author copy | 436,99 kB | Adobe PDF | Ver/Abrir |