Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/22024
Título: | Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI |
Autor(es): | Ferreira, Miguel Filipe Moreira Marques Mousavi, Bibimaryam Ferreira, Paula M. T. Martins, Catarina Helm, Lothar Martins, José A. Geraldes, Carlos F. G. C. |
Palavras-chave: | Gold nanoparticles Gd3+ chelates Fast water exchange Kinetic inertness Safe for in vivo applications High relaxivity Contrast agents for MRI PH stability |
Data: | 2012 |
Editora: | Royal Society of Chemistry |
Revista: | Dalton Transactions |
Citação: | Dalton Trans., 2012,41, 5472-5475 |
Resumo(s): | Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM-1s-1, 30 MHz, 25 ºC) Contrast Agent potentially safe for in vivo MRI applications. The Lipari-Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The relaxivity is limited by chelate flexibility. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/22024 |
DOI: | 10.1039/c2dt30388d |
ISSN: | 0300-9246 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Gold NPs_Dalton_Reposit_UM.pdf | Documento principal e informação suplementar | 630,57 kB | Adobe PDF | Ver/Abrir |