Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/20265
Título: | Chitosan beads as templates for layer-by-layer assembly and their application in the sustained release of bioactive agents |
Autor(es): | Grech, Jessica M. R. Mano, J. F. Reis, R. L. |
Palavras-chave: | Layer-by-layer Chitosan beads Bead coatings Drug release Gentamicin delivery Controlled delivery Tissue engineering Scaffold |
Data: | 2008 |
Editora: | SAGE |
Revista: | Journal of Bioactive and Compatible Polymers |
Resumo(s): | Uncoated chitosan beads and chitosan beads coated with hyaluronic acid/chitosan (HA/Ch) multilayers, were used to investigate the controlled release of gentamicin sulphate (GS). Greater encapsulation efficiency was observed for the layer—by-layer multilayer coated beads. The in vitro drug release was in a slower sustained manner compared with noncoated chitosan beads. The differences in in vitro drug release results may be explained by the barrier effect of the coating that impedes diffusion of GS and supporting complementary water uptake. These findings indicated that a slower sustained release of gentamicin can be obtained using multilayer coatings of HA/Ch on chitosan beads and that this process could be used as a drug delivery system. In addition, agglomerates of these bead could provide a porous support in tissue engineering applications. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/20265 |
DOI: | 10.1177/0883911508093389 |
ISSN: | 0883-9115 1530-8030 |
Versão da editora: | http://jbc.sagepub.com/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |