Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/18664
Título: | Immunity and tolerance to infections in experimental hematopoietic transplantation |
Autor(es): | Carvalho, Agostinho Cunha, Cristina Romani, Luigina |
Palavras-chave: | Stem cell transplantation Fungal infections Immunity Inflammation Immunotherapy Single nucleotide polymorphism Genetic susceptibility Dendritic cells Epithelial cells |
Data: | Set-2011 |
Editora: | Elsevier 1 |
Revista: | Best Practice & Research. Clinical Haematology |
Resumo(s): | Resistance and tolerance are two types of host defense mechanisms that increase fitness in response to fungi. Several genetic polymorphisms in pattern recognition receptors, most remarkably Toll-like receptors (TLRs), have been described to influence resistance and tolerance to aspergillosis in distinct clinical settings. TLRs on dendritic cells pivotally contribute in determining the balance between immunopathology and protective immunity to the fungus. Epithelial cells also contribute to this balance via selected TLRs converging on indoleamine-2,3-dioxygenase (IDO). Studies in experimental hematopoietic transplantation confirmed the dichotomy of pathways leading to resistance and tolerance to the fungus providing new insights on the relative contribution of the hematopoietic/nonhematopoietic compartments. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/18664 |
DOI: | 10.1016/j.beha.2011.04.006 |
ISSN: | 1521-6926 |
Versão da editora: | http://www.sciencedirect.com/science/article/pii/S1521692611000429 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Carvalho A_Best Pract Res Clin Haematol-prep 2011.pdf | Versão preprint | 587,06 kB | Adobe PDF | Ver/Abrir |