Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/17465
Título: | Encapsulation and survival of a chondrocyte cell line within xanthan gum derivative |
Autor(es): | Mendes, Ana Carina Baran, Erkan Türker Pereira, Rui C. Azevedo, Helena S. Reis, R. L. |
Palavras-chave: | cell delivery microdroplet generator microencapsulation polysaccharides xanthan gum |
Data: | 2012 |
Editora: | Wiley |
Revista: | Macromolecular Biosciense |
Resumo(s): | A chemical derivative of xanthan gum polysaccharide is investigated as a new artificial matrix for the encapsulation of chondrocytic cells. Toward this goal, a novel micro-droplet generator is developed to produce microcapsules. Microcapsules with an average diameter of 500 mm, smooth surface, and homogeneous size distribution are obtained. ATDC5 cells encapsulated in carboxymethyl xanthan (CMX) microcapsules remain viable and are observed to proliferate for prolonged culture periods with enhanced metabolic activity. Furthermore, retention of the chondrogenic phenotype is exhibited by the cells within CMX, suggesting the ability of this material to be applied in cell-delivery therapies. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/17465 |
DOI: | 10.1002/mabi.201100304 |
ISSN: | 1616-5195 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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CMXantan_AnaMendes_MacromolBiosci2011_Onlinepublication.pdf | 1,01 MB | Adobe PDF | Ver/Abrir |