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https://hdl.handle.net/1822/17431
Título: | TLR2 deficiency by compromising p19 (IL-23) expression limits T helper 17 cell responses to Mycobacterium tuberculosis |
Autor(es): | Coelho, Maria Teixeira Cruz, Andrea Carmona, J. A. Sousa, Carole Lara Veiga de Pereira, Daniela Maria Ramos Saraiva, Ana Laura Veldhoen, Marc Pedrosa, Jorge Castro, António G. Saraiva, Margarida |
Palavras-chave: | Tuberculosis TLR IL-23 Cytokines |
Data: | Fev-2011 |
Editora: | Oxford University Press |
Revista: | International Immunology |
Resumo(s): | CD4+ Th1 cells producing IFN-γ are of extreme importance in controlling infections by Mycobacterium tuberculosis both in mice and in men. In addition to IFN-γ-producing T cells, IL-17-producing T cells (Th17) have been observed during mycobacterial infections. Nevertheless, their contribution for the host immune response to mycobacteria as well as the signals triggering M. tuberculosis -specific Th17 cell differentiation and maintenance are not fully understood. We show that signaling via Toll-like receptor (TLR) 2 has a major impact on the regulation of p19 (IL-23) expression in response to M. tuberculosis and therefore on the establishment of Th17 cell responses to M. tuberculosis infection. Diminished Th17 responses in the lung of M. tuberculosis -infected TLR2-deficient animals were not caused by defective cell differentiation in the draining lymph node (LN) but rather by reduced maintenance at the site of infection. Consistent with the decreased numbers of Th17 cells in the lungs of infected TLR2-deficient animals, we observed reduced expression of CXCL9, CXCL10 and CXCL11, chemokines involved in recall responses to M. tuberculosis. Our data provides insights into the TLR2 role in infection with M. tuberculosis, with implications in pathophysiology of the disease and vaccine design. |
Tipo: | Artigo |
Descrição: | The authors are grateful to Drs. Manuel Teixeira da Silva, Fernando Rodrigues, Margarida Correia-Neves and Paul S. Redford for critically reading this manuscript and thank the personnel at the ICVS animal house facility for excellent animal husbandry. |
URI: | https://hdl.handle.net/1822/17431 |
DOI: | 10.1093/intimm/dxq459 |
ISSN: | 0953-8178 |
Versão da editora: | http://intimm.oxfordjournals.org/content/23/2/89.abstract |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Teixeira-Coelho M_Int Immunol 2011 pp.pdf | Versão postprint | 655,04 kB | Adobe PDF | Ver/Abrir |