Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/16890
Título: | Exploratory analysis of longitudinal trials with staggered intervention times |
Autor(es): | Sousa, Inês Chetwynd, Amanda G. Diggle, Peter |
Palavras-chave: | Back-fitting algorithm Cross-validation Longitudinal trials Nonparametric estimator |
Data: | Abr-2005 |
Editora: | Oxford University Press |
Revista: | Biostatistics |
Resumo(s): | Longitudinal trials involving surgical interventions commonly have subject-specific intervention times, due to constraints on the availability of surgeons and operating theatres. Moreover, the intervention often effects a discontinuous change in the mean response. We propose a nonparametric estimator for the mean response profile of longitudinal data with staggered intervention times and a discontinuity at the times of intervention, as an exploratory tool to assist the formulation of a suitable parametric model. We use an adaptation of the standard generalized additive model algorithm for estimation, with smoothing constants chosen by a cross-validation criterion. We illustrate the method using longitudinal data from a trial to assess the effect of lung resection surgery in the treatment of emphysema patients. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/16890 |
ISSN: | 1468-4357 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CMAT - Artigos em revistas com arbitragem / Papers in peer review journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Biostat-Sousa_Ines.pdf Acesso restrito! | 104,41 kB | Adobe PDF | Ver/Abrir |