Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/16089
Título: | MCM-based microlaboratory for simultaneous measurement of several biochemical parameters by spectrophotometry |
Autor(es): | Minas, Graça Wolffenbuttel, R. F. Correia, J. H. |
Palavras-chave: | MCM-based microlaboratory Biochemical parameters analysis Optical absorption Portability White light source Portability white light source |
Data: | 23-Abr-2010 |
Editora: | Springer |
Revista: | Biomedical Microdevices |
Resumo(s): | This paper reports on the concept, fabrication and characterization of a multi-chip module microlaboratory. The application is in the spectrophotometric analysis of human physiological fluids in a clinical setting. The system is composed of three stacked parts: (1) a central microfluidic system die containing the microchannels, which is fabricated by applying MEMS techniques to an SU-8 layer, (2) an optical filtering system on the top side, fabricated using a dielectric thin-films multilayer and (3) a detection and readout system on the bottom side, which is fabricated in a CMOS microelectronic process. The system modularity and emphasis on microfabrication provides potential for low unit cost. The application is the simultaneous and quantitative measurement of the concentration of four biochemical parameters in human physiological fluids by spectrally selective optical absorption. The intensity of the light transmitted through the physiological fluid results in an electrical output signal in the form of bit streams, which allows simple computer interfacing. A simple white light source is used for illumination, due to the optical filtering system, which makes the microlaboratory portable. The quantitative measurement of chloride, creatinine, total protein and uric acid in urine is successfully demonstrated. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/16089 |
DOI: | 10.1007/s10544-010-9426-1 |
ISSN: | 1387-2176 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | DEI - Artigos em revistas internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Biomed Microdevices 2010 V12 N4 p727–736.pdf Acesso restrito! | Documento principal | 500,27 kB | Adobe PDF | Ver/Abrir |