Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/15301
Título: | One-pot regioselective synthesis of 2,6,9-trisubstituted adenines |
Autor(es): | Dias, Alice Senhorães, Nádia Conde, Luís Proença, M. Fernanda R. P. |
Palavras-chave: | heterocycles cyclization ring closure ring opening imidazole purine |
Data: | 4-Jan-2011 |
Editora: | Thieme Medical Publishers |
Revista: | Synlett |
Resumo(s): | A series of 2,6,9-substituted adenines were obtained from the easily accessible 5-amino-4-cyanoformimidoyl imidazoles 1, acetic and benzoic anhydrides and primary alkyl amines in a three-steps sequence. Acylation of 1 followed by addition of the amine led to the intermediates 5-amino-4-(N-acyl)formamidino imidazoles 4/5, under mild conditions. Cyclization of 4/5 under reflux in ethanol led to the desired substituted adenine. A preliminary stepwise study led to the development of three general and efficient one-pot methods for the synthesis of adenine derivatives. The one-pot three-step reaction in the presence of DMAP was the most convenient syn-thetic approach. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/15301 |
DOI: | 10.1055/s-0030-1259289 |
ISSN: | 0936-5214 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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One-Pot Regioselective Synthesis of 2,6,9-Trisubstituted Adenines.pdf Acesso restrito! | Documento Principal | 149,67 kB | Adobe PDF | Ver/Abrir |