Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/14267
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Fontes, André Filipe Gomes Soares | - |
dc.contributor.author | Prata, M. Isabel M. | - |
dc.contributor.author | Geraldes, Carlos F. G. C. | - |
dc.contributor.author | André, João P. | - |
dc.date.accessioned | 2011-11-11T15:03:13Z | - |
dc.date.available | 2011-11-11T15:03:13Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0969-8051 | por |
dc.identifier.uri | https://hdl.handle.net/1822/14267 | - |
dc.description.abstract | In this work we report a synthetic strategy of amphiphilic DOTA-based chelators bearing a variable size α-alkyl chain at one of the pendant acetate arms (from six to fourteen carbon atoms), compatible with their covalent coupling to amine-bearing biomolecules. The amphiphilic behavior of the micelles-forming Ga(III) chelates (critical micelle concentration), their stability in blood serum and their lipophilicity (logP) were investigated. Biodistribution studies with the 67Ga-labeled chelates were performed in Wistar rats showing a predominant liver uptake with almost no traces of the radiochelates in the body after 24 hours. | por |
dc.description.sponsorship | Fundação para a Ciência e a Tecnologia (FCT) | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier 1 | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/70063/PT | - |
dc.rights | openAccess | por |
dc.subject | DOTA | por |
dc.subject | Gallium | por |
dc.subject | Amphiphilic | por |
dc.subject | Micelles | por |
dc.subject | Radiopharmacy | por |
dc.subject | PET | por |
dc.title | Ga(III) chelates of amphiphilic DOTA-based ligands : synthetic route and in vitro and in vivo studies | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://www.elsevier.com/wps/find/journaldescription.cws_home/525482/description | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 363 | por |
oaire.citationEndPage | 370 | por |
oaire.citationIssue | 3 | por |
oaire.citationTitle | Nuclear Medicine and Biology | por |
oaire.citationVolume | 38 | por |
dc.identifier.doi | 10.1016/j.nucmedbio.2010.10.003 | por |
dc.identifier.pmid | 21492785 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Nuclear Medicine and Biology | por |
Aparece nas coleções: | CDQuim - Artigos (Papers) |