Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/14067
Título: | Bonelike/PLGA hybrid materials for bone regeneration : preparation route and physicochemical characterisation |
Autor(es): | Oliveira, Joaquim M. Miyazaki, T. Lopes, M. A. Ohtsuki, C. Santos, J. D. |
Data: | 2005 |
Revista: | Journal of Materials Science: Materials in Medicine |
Resumo(s): | Bonelike R /PLGA hybrid materials have been developed using γ -MPS as silane-coupling agent between the inorganic and organic phases for controlled drug delivery applications. Silanization showed to be more effective when cyclohexane was used as a non-polar solvent (nP method) due to a chemical interaction between Bonelike R and the silane film, while by using a 95/5 (V/V) methanol/water as a polar solvent (P method), a much thinner film was achieved. Functional groups of PLGA, such as the carbonyl group (C O), were identified using Raman and FTIR-ATR analysis and therefore these groups may be used to link therapeutic molecules. These novel hybrid materials prepared by combining silanization and post-hybridisation processes are expected to find use in medical applications of bone regeneration and as drug delivery carrier for therapeutic molecules. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/14067 |
ISSN: | 0957-4530 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |