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https://hdl.handle.net/1822/14026
Título: | Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles |
Autor(es): | Link, Dennis P. Van den Dolder, Juliette Jurgens, J. F. M. Wolke, Joop G. Jansen, John A. |
Palavras-chave: | Injectable CaP/PLGA cement Mechanical properties; Bone ingrowth |
Data: | 2006 |
Editora: | Elsevier 1 |
Revista: | Biomaterials |
Resumo(s): | In this study, the mechanical properties of an implanted calcium phosphate (CaP) cement incorporated with 20wt% poly (DL-lactic-coglycolic acid) (PLGA) microparticles were investigated in a rat cranial defect. After 2, 4 and 8 weeks of implantation, implants were evaluated mechanically (push-out test) and morphologically (Scanning Electron Microscopy (SEM) and histology). The results of the push-out test showed that after 2 weeks the shear strength of the implants was 0.4470.44MPa (average7sd), which increased to 1.3471.05MPa at 4 weeks and finally resulted in 2.6072.78MPa at 8 weeks. SEM examination showed a fracture plane at the bone–cement interface at 2 weeks, while the 4- and 8-week specimens created a fracture plane into the CaP/PLGA composites, indicating an increased strength of the bone–cement interface. Histological evaluation revealed that the two weeks implantation period resulted in minimal bone ingrowth, while at 4 weeks of implantation the peripheral PLGA microparticles were degraded and replaced by deposition of newly formed bone. Finally, after 8 weeks of implantation the degradation of the PLGA microparticles was almost completed, which was observed by the bone ingrowth throughout the CaP/PLGA composites. On basis of our results, we conclude that the shear strength of the bone–cement interface increased over time due to bone ingrowth into the CaP/PLGA composites. Although the bone–cement contact could be optimized with an injectable CaP cement to enhance bone ingrowth, still the mechanical properties of the composites after 8 weeks of implantation are insufficient for load-bearing purpose. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/14026 |
ISSN: | 0142-9612 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |