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https://hdl.handle.net/1822/10888
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Campo DC | Valor | Idioma |
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dc.contributor.author | Azevedo, Marisa | - |
dc.contributor.author | Camsari, Çagri | - |
dc.contributor.author | Sá, Carla M. | - |
dc.contributor.author | Lima, Cristóvão F. | - |
dc.contributor.author | Ferreira, Manuel Fernandes | - |
dc.contributor.author | Wilson, Cristina Pereira | - |
dc.date.accessioned | 2010-09-16T16:01:38Z | - |
dc.date.available | 2010-09-16T16:01:38Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://hdl.handle.net/1822/10888 | - |
dc.description.abstract | In the present study, two phytochemicals - ursolic acid (UA) and luteolin-7-glucoside (L7G) - were assessed in vivo in healthy rats regarding effects on plasma glucose and lipid profile (total cholesterol, HDL and LDL), as well as liver glycogen content, in view of their importance in the aetiology of diabetes and associated complications. Both UA and L7G significantly decreased plasma glucose concentration. UA also significantly increased liver glycogen levels accompanied by phosphorylation of glycogen synthase kinase-3 (GSK3). The increase in glycogen deposition induced by UA (mediated by GSK3) could have contributed to the lower plasma glucose levels observed. Both compounds significantly lowered total plasma cholesterol and low-density lipoprotein levels, and, in addition, UA increased plasma high-density lipoprotein levels. Our results show that UA particularly may be useful in preventable strategies for people at risk of developing diabetes and associated cardiovascular complications by improving plasma glucose levels and lipid profile, as well as by promoting liver glycogen deposition. | eng |
dc.description.sponsorship | MFA and CMS were supported by the Foundation for Science and Technology, Portugal, through the grants SFRH/BD/12527/2003 and SFRH/BD/42566/2007, respectively. This work was supported by the Foundation for Science and Technology, Portugal, research grant POCI/AGR/62040/2004. | por |
dc.language.iso | eng | por |
dc.publisher | John Wiley and Sons | por |
dc.relation | info:eu-repo/grantAgreement/FCT/POCI/62040/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F12527%2F2003/PT | - |
dc.relation | info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F42566%2F2007/PT | - |
dc.rights | openAccess | por |
dc.subject | Lamiaceae species | por |
dc.subject | Ursolic acid | por |
dc.subject | Luteolin-7-glucoside | por |
dc.subject | Lipid profile | por |
dc.subject | Liver glycogen | por |
dc.subject | Functional foods | por |
dc.title | Ursolic acid and luteolin-7-glucoside improves rat plasma lipid profile and increases liver glycogen content through glycogen synthase kinase-3 | por |
dc.type | article | por |
dc.peerreviewed | yes | por |
sdum.publicationstatus | submitted | por |
oaire.citationStartPage | S220 | por |
oaire.citationEndPage | S224 | por |
oaire.citationIssue | SUPPL. 2 | por |
oaire.citationVolume | 24 | por |
dc.identifier.doi | 10.1002/ptr.3118 | por |
dc.identifier.pmid | 20127879 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Phytotherapy Research | por |
Aparece nas coleções: | DBio - Artigos/Papers |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Azevedo et al_Phytotherapy Research_2010.pdf | 257,19 kB | Adobe PDF | Ver/Abrir |